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KMID : 0191120220370270210
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Journal of Korean Medical Science
2022 Volume.37 No. 27 p.210 ~ p.210
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Immunogenicity and Reactogenicity of Ad26.COV2.S in Korean Adults: A Prospective Cohort Study
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Hyun Hak-Jun
Choi Min-Joo
Heo Jung-Yeon
Seo Yu-Bin
Nham Eliel
Yoon Jin-Gu
Seong Hye
Noh Ji-Yun
Cheong Hee-Jin
Kim Woo-Joo
Choi Ju-Yeon
Lee Young-Jae
Lee Hye-Won
Kim Sung-Soon
Kim Byoung-Guk
Song Joon-Young
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Abstract
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Background: As the coronavirus disease 2019 (COVID-19) pandemic continues, there are concerns regarding waning immunity and the emergence of viral variants. The immunogenicity of Ad26.COV2.S against wild-type (WT) and variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) needs to be evaluated.
Method: This prospective cohort study was conducted between June 2021 and January 2022 at two university hospitals in South Korea. Healthy adults who were scheduled to be vaccinated with Ad26.COV2.S were enrolled in this study. The main outcomes included anti-spike (S) IgG antibody and neutralizing antibody responses, S-specific T-cell responses (interferon-γ enzyme-linked immunospot assay), solicited adverse events (AEs), and serious AEs.
Results: Fifty participants aged ≥ 19 years were included in the study. Geometric mean titers (GMTs) of anti-S IgG were 0.4 U/mL at baseline, 5.2 ± 3.0 U/mL at 3?4 weeks, 55.7 ± 2.4 U/mL at 5?8 weeks, and 81.3 ± 2.5 U/mL at 10?12 weeks after vaccination. GMTs of 50% neutralizing dilution (ND50) against WT SARS-CoV-2 were 164.6 ± 4.6 at 3-4 weeks, 313.9 ± 3.6 at 5?8 weeks, and 124.4 ± 2.6 at 10?12 weeks after vaccination. As for the S-specific T-cell responses, the median number of spot-forming units/106 peripheral blood mononuclear cell was 25.0 (5.0?29.2) at baseline, 60.0 (23.3?178.3) at 5-8 weeks, and 35.0 (13.3?71.7) at 10?12 weeks after vaccination. Compared to WT SARS-CoV-2, ND50 against Delta and Omicron variants was attenuated by 3.6-fold and 8.2-fold, respectively. The most frequent AE was injection site pain (82%), followed by myalgia (80%), fatigue (70%), and fever (50%). Most AEs were grade 1?2, and resolved within two days.
Conclusion: Single-dose Ad26.COV2.S was safe and immunogenic. NAb titer and S-specific T-cell immunity peak at 5?8 weeks and rather decrease at 10?12 weeks after vaccination. Cross-reactive neutralizing activity against the Omicron variant was negligible.
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KEYWORD
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SARS-CoV-2, COVID-19, Vaccines, Adenovirus Vector, Humoral Immunity, Cellular Immunity, Adverse Events
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